CD-MS Analytical Characterization

Accurate Macromolecular Mass Measurement

Our Solutions

  • Advanced AAV Analytics

    Advanced AAV Analytics

    CD-MS methods offer comprehensive AAV analytics, including:

    ✵    Assessments of empty, partial, and full capsid ratios

    ✵    Analysis of viral protein ratios

    ✵    DNA packaging analysis

    Applicable to a variety of samples:

    ✵    Upstream cell lysates

    ✵    Purified downstream products

  • Oligonucleotide Analysis

    Nucleotide Analysis

    High-resolution mass and charge measurements can analyze:

    ✵   mRNA

    ✵   Plasmids

    ✵   Single-stranded DNA (ssDNA)

    ✵   Double-stranded DNA (dsDNA)

    ✵   DNA nanostructures

    Capable of detecting:

    ✵    Genome truncations

    ✵    Structural analysis

  • VLPS and Oncolytic Viruses

    VLPs and Oncolytic Viruses

    CD-MS analysis can:

    ✵   Resolve assembly intermediates

    ✵   Quantify intact assembly products of Virus-Like Particles (VLPs)

    Leveraging CD-MS results allows researchers to:

    ✵   Optimize VLP methods for uniform assembly of end product structures

    Broad mass range of CD-MS enables:

    ✵   Assessment of empty/full ratios in large viral vectors

  • CD-MS Vaccines

    Vaccines

    CD-MS assays are developed for:

    ✵  Characterizing the structure and stoichiometry of antigen in drug product

    ✵  Probing antibody binding affinity to target antigen

    ✵  Investigating the stability of vaccine antigens from pre-formulation to final products

    Advantages of CD-MS include:

    ✵   High-throughput capabilities

    ✵   Broad scan range for effective analysis of complex mixtures

  • Non-Viral Nanoparticles

    Non-Viral Nanoparticles

    Mass and charge measurements offer insights into:

    ✵    Density of non-viral nanoparticles

    ✵    Polydispersity of non-viral nanoparticles

    Mass analysis can be used to:

    ✵    Quantify particle conjugation

    ✵    Assess loading effectiveness

Request a Demo Analysis

Recent Publications

  • Realization of Higher Resolution Charge Detection Mass Spectrometry

    Anal. Chem. 2024, 96, 34, 14060–14067

  • Charge Detection Mass Spectrometry Reveals Favored Structures in the Assembly of Virus-Like Particles: Polymorphism in Norovirus GI.1

    Anal. Chem. 2024, 96, 32, 13150–13157

  • Complementary Nanoparticle Characterization by Resistive-Pulse Sensing, Electron Microscopy, and Charge Detection Mass Spectrometry

    Anal. Chem. 2024, 96, 35, 14239–14247

  • Recombinant AAV genome size effect on viral vector production, purification, and thermostability

    Molecular Therapy Methods & Clinical Development, Volume 32, Issue 1, 101188

  • Quantitative analysis of preferential utilization of AAV ITR as the packaging terminal signal

    Front. Bioeng. Biotechnol., Volume 11 - 2023

  • Partial genome content within rAAVs impacts performance in a cell assay-dependent manner

    Molecular Therapy Methods & Clinical Development, Volume 30, 288 - 302

Request a Copy

Meet the Team

  • Martin Jarrold

    Martin Jarrold

    Chief Executive Officer

    Connect
  • David Clemmer

    David Clemmer

    Chief Operating Officer

    Connect
  • Benjamin E Draper

    Benjamin E Draper

    Analytical Lead

    Connect
  • Lohra Miller

    Lohra Miller

    Assay Development Lead

    Connect

  • Megadalton Solutions originated from Martin Jarrold's pioneering work in advancing CD-MS at Indiana University. This research has resulted in 22 patents and over 60 publications in the field. Today, Megadalton Solutions stands at the forefront of large molecule characterization and advanced instrumentation development, driving innovation and excellence in the industry.

  • We provide solutions to some of the most complex challenges in biophysical characterization. Our CD-MS technologies are designed to measure mass, structure, and purity across various modalities. Moreover, all results are analyzed and interpreted by our PhD experts in CD-MS, ensuring you receive the highest level of insight and accuracy.

  • At Megadalton Solutions, our CD-MS technology delivers the highest throughput and resolution for mass measurement of large molecules. Our team of experts is ready to assist you with data interpretation and drug filing preparations.

    Additionally, we have extensive experience in method optimization and the development of self-assembled particles. Let us help you achieve your goals.

  • Email us at contact@megadaltonsolutions.com to kick off a conversation. With some of the fastest turnaround times in the industry, our CD-MS analysis provides quick and reliable solutions to your characterization challenges. We look forward to helping you!

 FAQs

Get in touch.

Getting started with CD-MS is easier than you think. Send us a message and we will respond within 24 hours.