CDMS mass spectrum of ATCC Human Ad5 virus shows resolved full, partial, empty and incomplete particles of adenovirus. Adenovirus is comprised of over 2000 individual building blocks and the mass information from CDMS can not only differentiate particles, but give stoichiometry. CDMS has also been used to track the amount of packaging protein in different recombinant adenovirus lots. Check our the publication below.
CDMS mass histogram of the Inactivated Polio Vaccine (iPOL). CDMS can quantify the relative abundances of the desired capsid at ~8MDa as well as the peak ~6 MDa that is not responsible for an immune response. iPol is one vaccine example, but CDMS can measure all classical and next generation approaches providing information on lot-to-lot variability
Assembly of cp149 HBV capsid. The assembly and aggregation of protein complexes is difficult to characterize by most analytical techniques, but early stage resolving power of CDMS allows us to resolve the addition of individual subunits from early nucleation to the intact capsid